How to Choose a Syringe Filter Suitable for Your Applications

Filtration speed difference

With good effect on protecting the chromatography column and chromatography system, the syringe filter is mainly used for filtering of flow phases and samples in chromatography to improve the sensitivity and accuracy of the analysis results. If not, there might be impurities in the sample and solvent which will damage to chromatographic instruments and pillars, and also have a great impact on the analysis results. The syringe filter is widely used in protein removal and sterile test, drug analysis,environmental monitoring, and food test and so on.

HAWACH syringe filter is in high quality, with PP shell of chemical stability, which is made into different colors to facilitate the distinction of users. At the same time, the specification name is marked on the product to avoid confusion. WIth standard interface, it’s easy to connect with other types and has become an ideal choice for laboratory filter samples. To choose a suitable syringe filter, you need to focus on the following factors:

1. What is the chemical compatibility of the filter?
2. How much effective filtration area does filter be filtered?
3. What are the best pores required for sample purification?
 Sterile Hydrophilic PTFE Syringe FiltersSterile PVDF Syringe FiltersSterile MCE Syringe Filters

1. Consider chemical compatibility

Does the filter have to withstand the ability to tolerate acid, alkali or organic solvents? When selecting samples to prepare needle filters or flow phase filter filters according to the application, it is necessary to focus on its chemical compatibility.

Water - like sample

When filtering water samples, hydrophilic filter membranes are favored due to their affinity. They can use HAWACH filters equipped with hydrophilic polypropylene, PES, nylon or PVDF syringe Filters.

Gas and erosion organic solvents

The hydrophobic filter exclusion water is inert for corrosive organic solvents, which has become the first choice for gas and organic solvent treatment. You can choose a HAWACH PTFE syringe filter equipped with PTFE filter membrane.

Aquatic solution and organic solution

The filter membranes of different polymers have different chemical compatibility. Generally, due to the limitation of hydrophobic/hydrophilicity and chemical compatibility, a single type of filter cannot be competent for all applications.

Very low extraction level

Filters are used to remove unnecessary particles to improve accuracy. However, inappropriate filters may make it a source of pollutants. The extract can be eluted from the filter device and entered the sample. These unnecessary illustrations will endanger the accuracy of the analysis results, and some problems caused by extracts include: common elution, quantitative errors, and external peak values.

2. Select the best effective filtration area

The particles contained in the fluid affect the service life of the syringe filter. The particles removed from the fluid will block the micropores of filter membranes and reduce the available ratio of the filter. Generally, compared with the "clean" fluid, the fluid with a high particle concentration will blocked the filter faster. Increasing the effective filtration area can extend the service life of the filter.

The size of the syringe filter is diverse, from the filter area in a single micropore on the 96 -hole filter, until the centrifugal filter and needle filter. When dealing with smaller samples, you can also choose a needle -type filter with a diameter of 13mm or 4mm. All filters have a variety of filter membranes and pores for selection.

Another factor that selects the size of the syringe filter is the residual volume, that is, the residual fluid volume after the filter is used. When dealing with high or extremely precious fluids, it is recommended to use a low -residue syringe filter. How much device size is needed to reduce the residual volume and ensure the complete filtering of the sample? Hawach provides a variety of devices to choose from.

Consider pre -filtering

For samples that are difficult to filter, it is best to use a syringe filter with glass fiber pre -filter membrane on it.

3.Best pores required for sample purification

Select the appropriate pore size according to the analysis requirements. The UV/V optic photogenic meter may only require 1um filtering; HPLC analysis may require 0.45um filtration, UHPLC will require 0.2um filtration. Due to the volume, fillers and gaps, the pore size of the filter material depends on the minimum particle diameter. These particles will effectively intercept the filter of the rated aperture.

The rated pore level is used as a general indicator retained by the membrane of the syringe filter. It is understood that some particles greater than or equal to the rated aperture will enter the filter through the filter membrane. Some manufacturers may associate the nominal pore rated value with the percentage of filtration efficiency. The nominal aperture level varies from manufacturers, so it is not necessarily equal. Regardless of the size of the aperture, it is important to understand the conditions of the use of the particles. Even a filter with aperture rated value can run under the condition that the size exceeds the expected particles.

Click here to know How to Sterilize Syringe Filters? Several Common Materials And Advantage For Syringe Filter

01/05/2023