What Are MCE Filters Used for?

What is MCE material?

The shell material of the MCE syringe filter is made of high-quality sanitary polypropylene material. MCE is a mixture of nitrocellulose and cellulose acetate. The product structure is designed with precision, which ensures smooth filtration, rationalization of internal space, and very low residual rate, thus reducing the waste of samples.

Syringe filters can be divided into many different types based on different classifications and they are widely used in many industries, like the environmental testing, liquid and gas phase sample preparation; removal of protein precipitates; routine QC testing and dissolution assays, etc. There are different types of filter membranes available in HAWACH, such as Nylon, PVDF, PES, PP, PTFE and MCE and so on.

There are many different types of syringe filters, which is classified with the filter membrane materials. Today, we will focus on the MCE syringe filter which refers to the filter membrane made of refined nitrocellulose, adding appropriate amount of cellulose acetate, acetone, n-butanol, ethanol, etc. It is hydrophilic, non-toxic and hygienic. It is a porous membrane filter material. The pore size distribution is relatively uniform penetrating micropores with a microporosity of up to 80‰. The mixed cellulose ester(MCE) syringe filter is mainly used for the filtration of water-based solutions, so it is also called water-based membrane. The MCE syringe filter is flammable and should be sealed, moisture-proof and fire-proof when stored. The membrane made of mixed cellulose is a standard common filter membrane. Low, low protein adsorption. It is used for chemotaxis and cell retention, particle collection, and is also commonly used for ultra-clean filtration of solutions and light scattering measurements, as well as aqueous solution sterile filtration. Filters can be normally sterilized at 121°C without loss of integrity. The surface is smooth, the texture is light and thin, the porosity is high, and the microporous structure is uniform, so it has the characteristics of fast flow rate and difficult adsorption.

MCE syringe filter is used for water quality in pharmaceuticals, biological products, mineral pump beverages, brewing, watches and other industries. It is used for medical oil, lubricating oil, fuel oil and scientific research laboratory to filter bacteria and particles. Generally, particles above 0.65 microns can be removed, and bacteria below 0.45 can be removed.

MCE Syringe FiltersMCE Syringe FiltersMCE Syringe Filters

Applications of MCE syringe filter

The MCE syringe filter has good hydrophilicity, high porosity and high filtration speed, and is mainly used for: 1) sterilization and particle removal in laboratory and small-scale processes; 2) culture sterilization and filtration of base and culture solution; 3) Determination of bacterial flora in water. To be more specific:

1. For the pharmaceutical industry that needs autoclaving, water injection, large infusion, extraction of traditional Chinese medicine, and beverage filtration to remove particulates can improve the intrinsic quality of the drug and the pass rate of brightness, and remove heat-sensitive drugs (insulin ATP, coenzyme A and other biochemical preparations). Use a 0.45-micron syringe filter (or 0.3-micron, 0.2-micron filter) to test for sterility by the membrane method of antibiotics.
2. Medicine and hygiene, the detection of C-AMP, C-GMP and bloodworms in human body fluids by the film method, and the detection of Escherichia coli in drinking water, surface water and well water.
3. Analysis and determination of particles and oil insolubles in solution, and determination of water pollution index.
4. It is used in scientific research departments such as somatic hybridization and mitochondrial complementation prediction of heterosis research.
5. Fine filtration of high-purity water in the electronics industry, etc.
6. Analysis of ambient air, waste gas and water.
7. Microelectronic semiconductor, chemical industry, cement/mineral analysis, etc.
8. Testing and analysis of raw materials, finished products and semi-finished products of food, beverages and medicines.
9. Filtration of aqueous and organic solutions in educational and commercial R&D laboratories.
10. Teaching, quality inspection, quality control; sample preparation for chromatography and mass spectrometry.
11. The sterilization filter does not need to change the membrane and clean the filter, which saves the complicated and time-consuming preparation work, and is widely used in the laboratory.
12. Sterilization filters are mainly used for pre-clarification of samples, particle removal, sterilization filtration of liquids and gases, etc. Among them, needle filters are used together with disposable syringes, which are fast, convenient and reliable for routine use in laboratories. Filter processing unit for small volume samples.

MCE Syringe Filters

MCE syringe filter Use notes

1. Put the MCE filter membrane flat in the clean container, soak it in distilled water of about 70 degrees to make it all wet. After a few hours (about 4 hours or more), pour out the water and soak it overnight using the above method. Before use, soak and wash with an appropriate amount of warm distilled water.
2. Put the cleaned MCE filter membrane into a suitable filter to prevent the surrounding liquid from leaking, put the filtrate from the liquid inlet, and exhaust the air at the exhaust port to filter.
3. MCE syringe filter is suitable for liquid medicine with PH2-9, and should not be used for strong acid and alkali or organic solvent including alcohol.
4. This product generally has a temperature resistance of 130 degrees and a pressure resistance of 3-4 kg/square centimeter.
5. The filter membrane can only be used as the final stage of filtration, and the filtrate must be pre-filtered by the plate frame or other filter materials to prevent the filter membrane from being blocked.
6. The above method of use: only suitable for the filtration of liquid medicine or other water solvents.
7. It must be used with disposable syringes and glass syringes. The interface is standard. First put the syringe filter on the syringe, then pour the liquid into the syringe, press the push rod down, and collect the filtered.
8. Do not use a syringe smaller than 10 cc, as the small volume of the column may cause the pressure to exceed the upper limit, resulting in membrane damage.
9. For laboratory use only, single use, non-renewable.
10. A portion of the filtrate at the beginning should be discarded, the volume is about the dead volume of the filter, taking 25 mm as an example, the first 1 mL of filtrate should be discarded; or the filter should be pre-washed with 1 to 2 mL of the solution.
11. When using the MCE syringe filter, keep the membrane wet. Due to due to disinfection, it becomes dry and then must use sterile water to wet it. If the wetting is not good, the flow rate must be affected. , and then carry out sterilization filtration in a sterile room, which should be carried out in strict accordance with the sterilization operation procedures, using filter membranes with nominal pore sizes of 0.45 microns, 0.3 microns, and 0.2 microns.
12. When the filtrate is below 0.025 micron, it is not suitable to use syringe filtration. It only has adsorption effect on the heat source virus and cannot be completely removed.

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05/17/2023